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def set_up(props=None):
"""
A func to set up run that can also be used by test code.
"""
init_props(MODEL_NAME, props)
drinkers = Composite(DRINKERS, {"color": RED},
member_creator=create_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
non_drinkers = Composite(NON_DRINKERS, {"color": BLUE},
member_creator=create_non_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
bar = Env(MODEL_NAME,
height=get_prop('grid_height', DEF_HEIGHT),
width=get_prop('grid_width', DEF_WIDTH),
members=[drinkers, non_drinkers],
pop_hist_setup=setup_attendance)
population = len(drinkers) + len(non_drinkers)
bar.set_attr("population", population)
bar.set_attr(OPT_OCCUPANCY, int(population * DEF_MOTIV))
def set_up(props=None):
"""
A func to set up run that can also be used by test code.
"""
init_props(MODEL_NAME, props)
drinkers = Composite(DRINKERS, {"color": RED},
member_creator=create_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
non_drinkers = Composite(NON_DRINKERS, {"color": BLUE},
member_creator=create_non_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
bar = Env(MODEL_NAME,
height=get_prop('grid_height', DEF_HEIGHT),
width=get_prop('grid_width', DEF_WIDTH),
members=[drinkers, non_drinkers],
pop_hist_setup=setup_attendance)
population = len(drinkers) + len(non_drinkers)
bar.set_attr("population", population)
bar.set_attr(OPT_OCCUPANCY, int(population * DEF_MOTIV))
bar.set_attr(AGENTS_DECIDED, 0)
bar.set_attr(ATTENDANCE, 0)
set_env_attrs()
def set_up(props=None):
"""
A func to set up run that can also be used by test code.
"""
init_props(MODEL_NAME, props)
drinkers = Composite(DRINKERS, {"color": RED},
member_creator=create_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
non_drinkers = Composite(NON_DRINKERS, {"color": BLUE},
member_creator=create_non_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
bar = Env(MODEL_NAME,
height=get_prop('grid_height', DEF_HEIGHT),
width=get_prop('grid_width', DEF_WIDTH),
members=[drinkers, non_drinkers],
pop_hist_setup=setup_attendance)
population = len(drinkers) + len(non_drinkers)
bar.set_attr("population", population)
bar.set_attr(OPT_OCCUPANCY, int(population * DEF_MOTIV))
bar.set_attr(AGENTS_DECIDED, 0)
bar.set_attr(ATTENDANCE, 0)
set_env_attrs()
def set_up(props=None):
"""
A func to set up run that can also be used by test code.
"""
init_props(MODEL_NAME, props)
drinkers = Composite(DRINKERS, {"color": RED},
member_creator=create_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
non_drinkers = Composite(NON_DRINKERS, {"color": BLUE},
member_creator=create_non_drinker,
num_members=get_prop('population',
DEF_POPULATION) // 2)
bar = Env(MODEL_NAME,
height=get_prop('grid_height', DEF_HEIGHT),
width=get_prop('grid_width', DEF_WIDTH),
members=[drinkers, non_drinkers],
pop_hist_setup=setup_attendance)
population = len(drinkers) + len(non_drinkers)
if merge:
groups = group_and_sort_statements(stmts)
for group in groups:
group_stmts = group[-1]
stmt_type = group[0][-1]
agent_names = group[0][1]
if len(agent_names) < 2:
continue
if stmt_type == 'Influence':
stmt = get_class_from_name(stmt_type, Statement)(
Event(Concept(agent_names[0])),
Event(Concept(agent_names[1])))
elif stmt_type == 'Conversion':
stmt = get_class_from_name(stmt_type, Statement)(
Agent(agent_names[0]),
[Agent(ag) for ag in agent_names[1]],
[Agent(ag) for ag in agent_names[2]])
else:
try:
stmt = get_class_from_name(stmt_type, Statement)(
Agent(agent_names[0]), Agent(agent_names[1]))
except ValueError:
stmt = get_class_from_name(stmt_type, Statement)(
[Agent(ag_name) for ag_name in agent_names])
ea = EnglishAssembler([stmt])
sentence = ea.make_model()
stmt_hashes = [gr_st.get_hash() for gr_st in group_stmts]
url_param = parse.urlencode(
{'stmt_hash': stmt_hashes, 'source': 'model_statement',
'model': self.model.name}, doseq=True)
link = f'/evidence?{url_param}'
sentences.append((link, sentence, ''))
db_ns, db_id = grounding.split(':')
# Assume UniProt or RefSeq IDs
assert db_ns in {'uniprotkb', 'refseq', 'ddbj/embl/genbank'}, db_ns
if db_ns == 'uniprotkb':
if '-' in db_id:
up_id, feat_id = db_id.split('-')
# Assume it's a feature ID
assert feat_id.startswith('PRO'), feat_id
db_refs = {'UP': up_id, 'UPPRO': feat_id}
else:
db_refs = {'UP': db_id}
elif db_ns == 'refseq':
db_refs = {'REFSEQ_PROT': db_id}
else:
db_refs = {'GENBANK': db_id}
agent = Agent(db_id, db_refs=db_refs)
standardized = standardize_agent_name(agent)
if up_web_fallback:
# Handle special case of unreviewed UP entries
if not standardized and 'UP' in db_refs:
name = uniprot_client.get_gene_name(db_refs['UP'],
web_fallback=True)
if name:
agent.name = name
return agent
position = None
ps = row['phosphosite']
kin_upid = row['KIN_ID']
if not pandas.isnull(kin_upid):
if kin_upid.find('-') != -1:
kin_upid = kin_upid.split('-')[0]
if not uniprot_client.is_human(kin_upid):
continue
kin_hgnc_symbol = uniprot_client.get_gene_name(kin_upid)
kin_hgnc = hgnc_client.get_hgnc_id(kin_hgnc_symbol)
else:
kin_hgnc_symbol = row['KINASE_GENE_SYMBOL']
if pandas.isnull(kin_hgnc_symbol):
continue
kin_hgnc_id = hgnc_client.get_hgnc_id(kin_hgnc_symbol)
kin_upid = hgnc_client.get_uniprot_id(kin_hgnc_id)
if kin_upid is None:
continue
kin = Agent(kin_hgnc_symbol,
db_refs={'UP': kin_upid, 'HGNC': kin_hgnc})
ev = Evidence(source_api='phosphosite')
st = Phosphorylation(kin, sub, residue, position, evidence = [ev])
statements.append(st)
return statements
def get_kinase_activities():
kinase_file = os.path.join(os.path.dirname(os.path.abspath(__file__)),
'../../resources/kinases.tsv')
kinases = []
with open(kinase_file, 'rt') as fh:
lines = [l.strip() for l in fh.readlines()]
for lin in lines[1:]:
up_id, hgnc_name, _, _ = lin.split('\t')
hgnc_id = hgnc_client.get_hgnc_id(hgnc_name)
agent = Agent(hgnc_name, db_refs={'UP': up_id, 'HGNC': hgnc_id})
kinases.append(agent)
kin_activities = []
from indra.statements import HasActivity
for kin in kinases:
stmt = HasActivity(kin, 'kinase', True)
kin_activities.append(stmt)
return kin_activities
db_refs={'UP': sub_upid,'HGNC': sub_hgnc})
residue = row['Actual_site'][0]
if len(row['Actual_site']) > 1:
position = row['Actual_site'][1:]
else:
position = None
ps = row['phosphosite']
kin_upid = row['KIN_ID']
if not pandas.isnull(kin_upid):
if kin_upid.find('-') != -1:
kin_upid = kin_upid.split('-')[0]
if not uniprot_client.is_human(kin_upid):
continue
kin_hgnc_symbol = uniprot_client.get_gene_name(kin_upid)
kin_hgnc = hgnc_client.get_hgnc_id(kin_hgnc_symbol)
else:
kin_hgnc_symbol = row['KINASE_GENE_SYMBOL']
if pandas.isnull(kin_hgnc_symbol):
continue
kin_hgnc_id = hgnc_client.get_hgnc_id(kin_hgnc_symbol)
kin_upid = hgnc_client.get_uniprot_id(kin_hgnc_id)
if kin_upid is None:
continue
kin = Agent(kin_hgnc_symbol,
db_refs={'UP': kin_upid, 'HGNC': kin_hgnc})
ev = Evidence(source_api='phosphosite')
st = Phosphorylation(kin, sub, residue, position, evidence = [ev])
statements.append(st)
return statements
def _build_uniprot_entries():
up_entries_file = os.path.dirname(os.path.abspath(__file__)) + \
'/../resources/uniprot_entries.tsv'
uniprot_gene_name = {}
uniprot_mnemonic = {}
uniprot_mnemonic_reverse = {}
uniprot_mgi = {}
uniprot_rgd = {}
uniprot_mgi_reverse = {}
uniprot_rgd_reverse = {}
try:
csv_rows = read_unicode_csv(up_entries_file, delimiter='\t')
# Skip the header row
next(csv_rows)
for row in csv_rows:
up_id, gene_name, up_mnemonic, rgd, mgi = row
uniprot_gene_name[up_id] = gene_name
uniprot_mnemonic[up_id] = up_mnemonic
uniprot_mnemonic_reverse[up_mnemonic] = up_id
if mgi:
mgi_ids = mgi.split(';')
if mgi_ids:
uniprot_mgi[up_id] = mgi_ids[0]
uniprot_mgi_reverse[mgi_ids[0]] = up_id
if rgd:
rgd_ids = rgd.split(';')
if rgd_ids:
uniprot_rgd[up_id] = rgd_ids[0]