How to use the pybel.dsl.Hgvs function in pybel

Gene('HGNC', 'AKT1', variants=Hgvs('c.308G>A')),
    tmprss2_erg_gene_fusion,
    Gene('HGNC', 'AKT1', variants=[Hgvs('c.1521_1523delCTT'), Hgvs('c.308G>A'), Hgvs('p.Phe508del')]),
    MicroRna('HGNC', 'MIR21'),
    bcr_jak2_gene_fusion,
    Gene('HGNC', 'CFTR', variants=Hgvs('c.1521_1523delCTT')),
    Gene('HGNC', 'CFTR'),
    Gene('HGNC', 'CFTR', variants=Hgvs('g.117199646_117199648delCTT')),
    Gene('HGNC', 'CFTR', variants=Hgvs('c.1521_1523delCTT')),
    Protein('HGNC', 'AKT1', variants=ProteinModification('Ph', 'Ser', 473)),
    MicroRna('HGNC', 'MIR21', variants=Hgvs('p.Phe508del')),
    Protein('HGNC', 'AKT1', variants=Hgvs('p.C40*')),
    Protein('HGNC', 'AKT1', variants=[Hgvs('p.Ala127Tyr'), ProteinModification('Ph', 'Ser')]),
    chchd4_aifm1_gene_fusion,
    tmprss2_erg_protein_fusion,
    Protein('HGNC', 'AKT1', variants=Hgvs('p.Arg1851*')),
    bcr_jak2_protein_fusion,
    Protein('HGNC', 'AKT1', variants=Hgvs('p.40*')),
    chchd4_aifm1_protein_fusion,
    Protein('HGNC', 'CFTR', variants=HgvsReference()),
    cftr,
    egfr,
    cftr_protein_unspecified_variant,
    adenocarcinoma,
    cftr_protein_phe_508_del,
    Protein('HGNC', 'MIA', variants=Fragment(5, 20)),
    mia,
    interleukin_23_complex,
    Protein('HGNC', 'MIA', variants=Fragment(1, '?')),
    Protein('HGNC', 'MIA', variants=Fragment()),
    Protein('HGNC', 'MIA', variants=Fragment(description='55kD')),
    Protein('HGNC', 'CFTR', variants=Hgvs('p.Gly576Ala')),

def test_multiple_variants(self):
        node_data = Gene('HGNC', 'AKT1', variants=[
            Hgvs('p.Phe508del'), Hgvs('p.Phe509del')
        ])
        node_parent_data = node_data.get_parent()
        node_parent_tuple = node_parent_data

        self.graph.add_node_from_data(node_data)
        self.assertIn(node_data, self.graph)
        self.assertIn(node_parent_tuple, self.graph)
        self.assertEqual(2, self.graph.number_of_nodes())
        self.assertEqual(1, self.graph.number_of_edges())

def test_psub_2(self):
        statement = 'sub(Ala, 127, Tyr)'
        result = self.parser.parseString(statement)

        expected_list = Hgvs('p.Ala127Tyr')
        self.assertEqual(expected_list, result.asDict())

CITATION: citation_1,
         RELATION: INCREASES,
     }),
    (Protein('HGNC', 'CFTR', variants=HgvsReference()), egfr, {
        EVIDENCE: dummy_evidence,
        CITATION: citation_1,
        RELATION: INCREASES,
        OBJECT: translocation(INTRACELLULAR, CELL_SURFACE),
    }),
    (cftr, Protein('HGNC', 'CFTR', variants=Hgvs('=')), {
        RELATION: HAS_VARIANT,
    }),
    (cftr, Protein('HGNC', 'CFTR', variants=Hgvs('?')), {
        RELATION: HAS_VARIANT,
    }),
    (cftr, Protein('HGNC', 'CFTR', variants=Hgvs('p.Phe508del')), {
        RELATION: HAS_VARIANT,
    }),
    (cftr, Protein('HGNC', 'CFTR', variants=Hgvs('p.Gly576Ala')), {
        RELATION: HAS_VARIANT,
    }),
    (mia, Protein('HGNC', 'MIA', variants=Fragment(5, 20)), {
        RELATION: HAS_VARIANT,
    }),
    (mia, Protein('HGNC', 'MIA', variants=Fragment(1, '?')), {
        RELATION: HAS_VARIANT,
    }),
    (mia, Protein('HGNC', 'MIA', variants=Fragment()), {
        RELATION: HAS_VARIANT,
    }),
    (mia, Protein('HGNC', 'MIA', variants=Fragment(description='55kD')), {
        RELATION: HAS_VARIANT,

def test_single_variant(self):
        node_data = Gene('HGNC', 'AKT1', variants=Hgvs('p.Phe508del'))
        node_parent_data = node_data.get_parent()

        self.graph.add_node_from_data(node_data)
        self.assertIn(node_data, self.graph)
        self.assertIn(node_parent_data, self.graph)
        self.assertEqual(2, self.graph.number_of_nodes())
        self.assertEqual(1, self.graph.number_of_edges())

def test_gsub(self):
        statement = 'sub(G,308,A)'
        result = self.parser.parseString(statement)

        expected_dict = Hgvs('c.308G>A')
        self.assertEqual(expected_dict, result.asDict())

bcr_jak2_protein_fusion,
    Protein('HGNC', 'AKT1', variants=Hgvs('p.40*')),
    chchd4_aifm1_protein_fusion,
    Protein('HGNC', 'CFTR', variants=HgvsReference()),
    cftr,
    egfr,
    cftr_protein_unspecified_variant,
    adenocarcinoma,
    cftr_protein_phe_508_del,
    Protein('HGNC', 'MIA', variants=Fragment(5, 20)),
    mia,
    interleukin_23_complex,
    Protein('HGNC', 'MIA', variants=Fragment(1, '?')),
    Protein('HGNC', 'MIA', variants=Fragment()),
    Protein('HGNC', 'MIA', variants=Fragment(description='55kD')),
    Protein('HGNC', 'CFTR', variants=Hgvs('p.Gly576Ala')),
    akt1_rna,
    Rna('HGNC', 'AKT1', variants=[Hgvs('c.1521_1523delCTT'), Hgvs('p.Phe508del')]),
    Gene('HGNC', 'NCF1'),
    ComplexAbundance([
        Gene('HGNC', 'NCF1'),
        Protein('HGNC', 'HBP1')
    ]),
    Protein('HGNC', 'HBP1'),
    ComplexAbundance([Protein('HGNC', 'FOS'), Protein('HGNC', 'JUN')]),
    Protein('HGNC', 'FOS'),
    Protein('HGNC', 'JUN'),
    Rna('HGNC', 'CFTR', variants=Hgvs('r.1521_1523delcuu')),
    Rna('HGNC', 'CFTR'),
    Rna('HGNC', 'CFTR', variants=Hgvs('r.1653_1655delcuu')),
    CompositeAbundance([
        interleukin_23_complex,

def test_protein_del(self):
        statement = 'variant(p.Phe508del)'
        expected = Hgvs('p.Phe508del')
        result = self.parser.parseString(statement)
        self.assertEqual(expected, result.asDict())

def test_snp(self):
        statement = 'var(c.1521_1523delCTT)'
        expected = Hgvs('c.1521_1523delCTT')
        result = self.parser.parseString(statement)
        self.assertEqual(expected, result.asDict())

def test_psub_1(self):
        statement = 'sub(A, 127, Y)'
        result = self.parser.parseString(statement)

        expected_list = Hgvs('p.Ala127Tyr')
        self.assertEqual(expected_list, result.asDict())